Causes of HAE

HAE is often hereditary, but not always

Hereditary angioedema (HAE) is called "hereditary" because literature suggests that about 75% of cases are passed down through families. About 25% of people with HAE have no family history at all. These cases result from a genetic change that happens spontaneously.

HAE and your family

A person who has a parent with HAE has a 50% chance of inheriting the condition.

• Since the gene responsible for HAE is a dominant gene, the person only needs one HAE gene from one parent to inherit the HAE condition.
• If a person does have HAE, there is a 50% chance he or she will pass it on to the next generation.
• If the person does not have HAE, he or she will not pass on HAE to his or her own children.